one. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This is often an impurity associated with bortezomib, a proteasome inhibitor Employed in the remedy of a number of myeloma. Its synthesis or review is critical for ensuring the purity and protection on the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-7): A precursor within the synthesis of abiraterone acetate, a drug Employed in the remedy of prostate most cancers by inhibiting androgen creation.
Imatinib Intermediate (CAS NO. 152460-10-one): A crucial compound while in the synthesis of imatinib, a drug that targets certain kinds of cancer, including Long-term myelogenous leukemia (CML).
Docetaxel Intermediate: A compound Utilized in the synthesis of docetaxel, a chemotherapy medication that treats different cancers such as breast, lung, and prostate cancer.
two. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, 8): These are definitely intermediates inside the synthesis of gemcitabine, an anti-most cancers drug. Their research is vital for optimizing the production course of action and making certain superior purity.
Lapatinib Intermediate (CAS NO. 231278-eighty four-5): Lapatinib is made use of to treat breast cancer, and these intermediates are linked to its manufacturing.
Fulvestrant Intermediates: Fulvestrant can be an estrogen receptor antagonist used in the treatment method of breast most cancers. Numerous intermediates assist in the synthesis of the drug.
Paclitaxel Facet Chain Acid (CAS NO. 949023-16-nine): This intermediate is used in the synthesis of paclitaxel, a N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine chemotherapy drug effective in treating cancers for example ovarian, breast, and lung cancer.
3. Other Noteworthy Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-three): A chemotherapy drug Employed in the therapy of colorectal cancer and compact mobile lung most cancers.
three-Amino-one-hydroxyadamantane (CAS 702-eighty two-nine): This compound is linked to the synthesis of adamantane derivatives, that have (3beta)- various applications, which includes antiviral Attributes.
Vildagliptin Intermediates: Employed in the creation of vildagliptin, an oral drug for style two diabetic issues that inhibits the enzyme DPP-four to control blood sugar degrees.
four. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 61259-forty eight-one): This compound is linked to the synthesis of assorted gluconic acid derivatives, that are used in foods, pharmaceutical, and industrial applications.
Canagliflozin Intermediate 2: A precursor during the synthesis of canagliflozin, a medication used to deal with form two diabetes by inhibiting sodium-glucose co-transporter two (SGLT2).